Vitamin D3 “Cholecalciferol” and Refrigeration Posted on March 11, 2010March 12, 2010Author Dr. Marcus EttingerPosted in Vitamin D3 (cholecalciferol) [Translate] Vitamin D3 (cholecalciferol) Softgels Q: Hi, Does the Vitamin D3 Softgels need to be refrigerated after opening? Thanks Julie A: Julie, That’s not needed and if you take it daily there will be do chance of it ever losing potency. Sincerely, Marcus Ettinger DC, BSc